• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Device for the hospital medical sector for diagnosis, tissue-induced regeneration by therapeutic percutaneous electrolysis and focal electro-stimulation based on the use of at least one bipolar needle comprising a very small area of two electrodes located in the outer and inner conductor of said bipolar needle, limiting the tissue to be treated in the area of the bevel of the needle without affecting the surrounding healthy tissue in which the electric signals necessary to diagnose the degree of degeneration are applied to said bipolar needle and calculate the necessary electric charge for the treatment of the injured tissue, taking control of this current in a way that eliminates the contraindications that currently exist. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2583159A1
    申请号:ES201500139
    申请日:2015-02-17
    公开日:2016-09-19
    发明作者:Josep OLIVER GARCÍA；Vicent ALEPUZ MONER
    申请人:Ionclinics And Deionic S L；Ionclinics And Deionic SL；
    IPC主号:
    专利说明:

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    DESCRIPTION
    Device for diagnosis and tissue-induced regeneration by therapeutic percutaneous electrolysis and focused electro-stimulation with bipolar needle.
    Technology Sector
    The present invention is framed in the field of electromedicine, particularly to devices intended for the diagnosis and treatment of degenerated tissues of the neuromusculoskeletal system by electrolysis and electro-stimulation.
    Background of the invention
    As is well known, electromedicine devices exist to achieve the regeneration and recovery of neuromusculoskeletal lesions based on electrolysis and electro-stimulation.
    The treatment based on percutaneous electrolysis currently uses two electrodes, anode and cathode, through which a direct current is induced in the affected tissue that is between these electrodes, causing heating and decomposition of the injured tissue. In the anode the main reaction is the decomposition of water taking place a reduction of the pH in its proximity while the reaction in the cathode gives rise to hydrogen in the gaseous state and hydroxyl ions, increasing the pH in the proximity of the cathode, producing a aggression to the affected soft tissues, and a subsequent inflammation necessary to start the regeneration and recovery process.
    The aforementioned effects, electrolysis and heating of the tissue, depend directly on the current density in circulation and the exposure time, where said current density depends on the current generated and the contact surface of the electrode.
    The technology of electrical stimulation, as is well known, is based on applying bipolar electrical impulses of low intensity and thereby stimulating the tissue with an analgesic, anti-inflammatory, relaxing or toning purpose and thus accelerating the recovery of damaged tissues.
    Electromedicine devices for the treatment of degenerated tissues of the neuromusculoskeletal system based on two physically separated electrodes are known in the state of the art to induce the passage of the galvanic current in order to initiate tissue regeneration between said electrodes, where the cathode is formed by a monopolar needle or isolated monopolar needle, it can be with teflon coating, which is applied percutaneously to the area of the damaged tissue, while the anode is formed by an electrode that can be held by hand or attached to the epidermis of the patient, as in the US patent US7725193 of the inventor Jennifer Chu or the device "Physio lnvasiva" of the company Enraf Nonius. In these cases, by having the physically separated electrodes, part of the electric current destined to the treatment of the injured tissue where the needle is located also circulates in part of the healthy tissue surrounding the injured one, reducing the effectiveness of the treatment due to the low focalization of the current in the area to be treated,
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    increasing possible side effects in healthy tissue due to the passage of current through it. The fact that this great distance between anode and cathode is required in these devices increases the existing bioimpedance between the two and forces to apply a greater potential difference between the electrodes to obtain the desired current. The electrical bioimpedance is higher because it affects all the tissue between the two electrodes, both the injured tissue and the healthy tissue, a problem solved by the invention recommended in this document.
    As a result of the fact that the galvanic current circulates between the two electrodes along this distance, this current can affect any pathology that can be found in its path, so in these teams there are contraindications to apply it to patients with endoprotesis and osteosynthesis, patients with pacemakers or any electronic implant, patients with cardiac problems, pregnant women, patients with malignant tumors and / or patients with thrombophlebitis.
    Devices and treatment techniques that use a bipolar signal by means of two electrodes consisting of the use of surface electrodes or monopolar needles are known, where depending on the lesion of the tissue to be treated and its depth, an alternating signal is applied between the two electrodes at a certain frequency, generally around 100Hz, in this frequency range the tissue bioimpedance is very high, so it is necessary to apply a very high voltage between the two electrodes, around 100V. These tensions so high, which may increase further as the lesion deepens, can affect all the tissue between the two electrodes, be it healthy tissue or injured tissue.
    On the other hand, devices using tetrapolar signals that solve the problem described above are known in which high voltages are required to achieve the desired current due to the high bioimpedance present in the tissues at the treatment frequency. These devices are based on generating an alternating current of a frequency between 1000 and 1000Hz between a pair of opposite electrodes, and on the other pair of electrodes, located 90 ° from the previous pair of electrodes, the same signal is generated but with a frequency shift in about 100Hz, which is the frequency of treatment and at the intersection of both signals in the area of the injured tissue to be treated, the mixing of both signals occurs, generating a signal modulated at the frequency resulting from the frequency difference between the stimulation currents and in this way, the electrical bioimpedance of the tissue is much lower avoiding the need to apply high voltages to achieve the desired current. Even so, there is still the same problem that occurs in the previous cases that the currents generated affect all the tissue between the electrodes, both healthy tissue and damaged tissue, being able to be the size of those affected tissues even greater if the Injury is deeper. There is also still the case that its use is not allowed in patients with endoprotesis and osteosynthesis, patients with pacemakers or any electronic implant, patients with cardiac problems, pregnant women, patients with malignant tumors and / or patients with thrombophlebitis.
    The device of the US patent US6058938 of the inventors Jennifer Chu and Peter Styles is known which make use of a bipolar needle as an electrode and a surface electrode as a return electrode to perform electro-stimulation to the patient in order for patients to experience less pain and discomfort during the procedure after the initial insertion of said needle, but unlike the invention recommended in the present invention in the case of trying to stimulate a tissue
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    Deep part of the healthy tissue will be affected by reducing the effectiveness of the treatment, in addition it does not have the capacity to make a diagnosis of the degree of degeneration of the injured tissue to calculate the current necessary to treat said tissue.
    There are patents and devices that use tissue impedance readings for localization and acupuncture treatment, not presenting a self-diagnostic ability to determine the degree of degeneration of the scanned tissue or means of adjusting the treatment signal, and the use of electrodes is also different. being therefore different from the recommended invention.
    After reviewing the state of the art, there is a need for an electromedicine device that is capable of providing the diagnosis and treatment by electrolysis or by electro-stimulation of degenerated tissues of the neuromusculoskeletal system focused on the area of the injured tissue to be treated without affecting the surrounding healthy tissue, unresolved situation in the state of the art.
    Consequently, the invention object of this patent allows to obtain the same treatment by reducing the necessary electric current because the treatment area is reduced, with less applied current we achieve the same current density in the treatment area and also a more accurate reading is obtained and It lowers the value of the electrical bioimpedance, since the electrical bioimpedance of the healthy tissue is not added, this prevents having to apply a high voltage to achieve the necessary current and also eliminates the contraindications existing in the current devices for the treatment as described previously.
    Object of the invention
    The object of the invention consists of an electromedicine device for the diagnosis and treatment through percutaneous electrolysis or electro-stimulation of degenerated tissues of the neuromusculoskeletal system capable of focusing treatment in the area of the injured tissue without affecting the surrounding healthy tissue and consequently reduce the values of treatment current getting an accurate reading of the value of the electrical bioimpedance of the damaged tissue interpreting the degree of degeneration of this without the value of the bioimpedance of the healthy tissue interfering, and thus avoiding the need to apply a high tension to generate the necessary current for its treatment, in addition to that said electromedicine device eliminates the contraindications that exist in current equipment such as patients with endoprotesis and osteosynthesis, patients with pacemakers or any electronic implant, patients with cardiac problems, pregnant women , patients with malignant tumors and / or patients with thrombophlebitis.
    Description of the invention
    The present invention describes an electromedicine device intended for diagnosis and treatment through percutaneous electrolysis or electro-stimulation of degenerated tissues of the neuromusculoskeletal system.
    There is a difference in impedance between healthy tissues and injured tissues when applying alternating signals of variable frequency, as demonstrated in the study on the electrical bioimpedances of healthy tissues and tissues with tendonitis "Electrical impedance spectroscopy and diagnosis of tendinitis" of several engineering departments medica,
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    pathology, physical medicine and rehabilitation of South Korea as well as the study "The dielectric properties of biological tissues" by the authors C. Gabriel, S. Gabriel and E. Corthout of the physical medicine department of King's College, London, so that When assessing the degree of tissue degeneration, a measurement of the electrical bioimpedance must be carried out with precision, for this purpose the measurement must be focused only on the affected tissue and there must always be the same distance between the two electrodes preventing the interference of the healthy tissue, for this reason the present invention is based on the use of at least one bipolar needle comprising in a very small area, the bevel, of two electrodes located in the outer and inner conductor of said bipolar needle, the area of the bevel It allows focusing only the area of the injured tissue to be treated without affecting healthy tissue.
    The fact that healthy tissue does not interfere with the measurement of electrical bioimpedance, allows to obtain lower values of said electrical bioimpedance, since it does not add the electrical bioimpedance of healthy tissue that is not needed and so! avoid applying high voltages to generate the electrical charge necessary to treat the injured tissue diagnosed.
    Therefore, means are available for self-diagnosis of the degree of tissue degeneration and subsequently to calculate the electrical charge necessary for electrolysis treatment, where these means are based, by at least one control logic in the analysis. of the electrical bioimpedance that the tissue presents when applying a sinusoidal signal of variable frequency by means of at least one alternating voltage generator comprising an oscillator that generates a clock signal towards a direct digital synthesizer (DDS) and a D / A converter to convert said digital signal into analog; a programmable amplifier stage responsible for amplifying the signal resulting from the digital / analog conversion and an impedance adapter to minimize the output error of the programmable amplifier stage; an I / V converter responsible for converting the current flowing through the tissue to be diagnosed to voltage. By applying said sinusoidal signal from the alternating voltage generator through a bipolar needle, a more precise actuation of the injured area of the tissue is achieved, without affecting the healthy tissues surrounding the damage, since said bipolar needle comprises in the same bevel of two electrodes limiting the tissue to be explored in the next area of said bevel.
    By applying said sinusoidal signal through the bipolar needle to the tissue for diagnosis, an electric current is induced that crosses the tissue between the two electrodes located in the bevel of the bipolar needle, where the intensity will depend on the electrical bioimpedance Present the scanned tissue. The electrical bioimpedance may vary depending on the frequency of excitation, the different types of tissue and their condition. Said induced current flowing between the two electrodes of the bipolar needle is measured allowing the calculation of the complex electrical bioimpedance of the explored tissue and its dissipation factor by Ohm's law.
    Generator:
    image 1
    Stream:
    I = 10 * sen (2nft + y)
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    Impedance:
    z = v7 = x, + usu, n
    Dissipation Factor:
    m
    The voltage obtained by means of the I / V converter is amplified by a programmable amplifier stage with impedance adapter and an A / D converter with low pass filter for signal processing; from said processed signal an algorithm is applied that allows to calculate the complex impedance and the dissipation factor of the diagnosed tissue where the results are stored in at least one memory for later comparison with values obtained from a sample of healthy tissue from the patient himself , control sample, or with values obtained from several clinical tests to calculate the degree of degeneration of the measured tissue and the electrical charge necessary for the electrolysis treatment to stimulate the regeneration of the damaged tissues through the same bipolar needle getting it applied only to the injured area of the patient's tissue without affecting the healthy tissues surrounding the damage as described.
    It is planned to have means for calibrating the device to avoid errors when performing the bioimpedance reading by means of a multiplexer controlled from the control logic that allows the selection to make the diagnosis through the bipolar needle or perform said calibration through at least one calibration impedance of known value that allows to know the impedance error that exists in the device, which will be compensated during the bioimpedance measurement of the tissue explored.
    Means for electrolysis treatment are available, selected by means of a multiplexer from the control logic, in which the calculated electric charge is applied to generate the focused electrolysis in the affected tissue without affecting the surrounding healthy tissue and avoiding the need of applying high voltages, where said means comprise at least one direct current source that applies the calculated electrical charge to the injured tissue through the electrodes, anode and cathode, which are located in the bevel area of a bipolar needle, where It has means for controlling said electric charge based on at least one ammeter that together with the control logic is responsible for limiting the electric charge delivered and detecting a current leak by controlling the current flowing through each electrode, anode and cathode, located on the bevel of said bipolar needle, so that both currents are compared to determine if they exceed a threshold level d The safety set by the control logic and the treatment is stopped, and at least one voltmeter that together with the control logic detects the potential difference between the two electrodes by calculating the impedance between both electrodes during the electrolysis treatment, so that if the calculated impedance exceeds a maximum or minimum set from the control logic, the treatment will be stopped, eliminating existing contraindications in patients with stents and osteosynthesis, patients with pacemakers or any electronic implant, patients with cardiac problems, pregnant women, patients with tumors malignant and / or patients with thrombophlebitis due to the focus of the treatment and the control of possible leakage currents.
    By using the bipolar needle and the safety means described above, the tissues affected by the electric charge are limited to the next area of the bevel of the
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    bipolar needle, totally limiting said electric charge through the injured tissue, without affecting the surrounding healthy tissue avoiding the need to apply high tensions and eliminating the contraindications existing in current devices.
    It has means to generate the focused electro-stimulation destined to stimulate the sensitive nerve fibers of the affected tissue in which bipolar pulsating signal signals are applied from the control logic through at least two bipolar needles, working these unipolar way using the conductor center of each needle as an electrode and the outer conductor as screening.
    Said pulsating signals are generated by at least one direct current generator that generates a current signal pattern formed by pulses of equal amplitude and duration, but 180 ° out of phase so that the average value of said signal is zero and prevents it from being produced. electrolysis phenomena. It also has means based on at least one ammeter and a voltmeter for the control of said pulsating signal based on the measurement of the current flowing through each electrode and the detection of a current leak measuring the current flowing through each electrode located in the central conductor of each needle so that both currents are compared to determine if it exceeds a safety threshold level set by the control logic and stops the stimulation, and also to detect the potential difference between the two electrodes and thus calculate the impedance present between both electrodes during the stimulation, so that if the calculated impedance exceeds a maximum or minimum set from the control logic, the stimulation will be stopped, and thus eliminate the contraindications existing in the patients described above.
    The use of at least two bipolar needles and / or at least two isolated monopolar needles, such as teflon coating, for diagnosis, treatment and electrostimulation is also planned.
    Brief description of the drawings
    To complement the description that is being made and in order to help a better understanding of the features of the invention, it is accompanied as an integral part of said description, where the following figures have been illustrated and not limited to:
    Figure 1 is the global block diagram of the invention where it is displayed:
    (1) Control module or logic
    (2) Electronic diagnostic module
    (3) Treatment module
    (4) Electro-stimulation module
    (5) Diagnostic / treatment selector multiplexer
    (25) Bipolar needle for diagnosis / treatment
    (26) Bipolar needles for focused electro-stimulation
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    In figure 2 view in profile and section of a bipolar needle where it is indicated:
    (6) Bevel section of a bipolar needle (7 and 8) Electrodes of a bipolar needle
    Figure 3 shows the block diagram of the electronic diagnostic module in which it is illustrated:
    (I) Control module or logic
    (9) Alternate voltage generator
    (10) Programmable amplifier
    (II) Impedance adapter
    (12) Bipolar needle selector or calibration multiplexer
    (13) Known impedance for equipment calibration
    (14) I / V converter
    (15) Amplifier
    (16) A / D converter
    (17) Algorithm to calculate electrical bioimpedance
    (18) Bioimpedance comparator
    (25) Bipolar needle for diagnosis / treatment
    Figure 4 illustrates the block diagram of the electrolysis treatment module where it is indicated:
    (1) Control module or logic
    (19) DC source
    (20) Intensity meters (anode and cathode)
    (21) Tension meter
    (25) Bipolar needle for diagnosis / treatment
    Figure 5 shows the block diagram of the electro-stimulation module in which it is illustrated:
    (1) Control module or logic
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    (22) DC source
    (23) Intensity meters
    (24) Tension meter
    (26) Bipolar needles for electro-stimulation Description of a preferred embodiment
    A preferred embodiment of the electromedicine device for the treatment of degenerated tissues of the neuromusculoskeletal system is described by way of example, the materials used in the manufacture of the device, as well as the methods of application and all methods of application being independent of the object of the invention. accessory details that may arise, as long as they do not affect their essentiality.
    The present invention employs at least one bipolar needle comprising in a very small area, the bevel (6), of two electrodes (7 and 8) located in the outer and inner conductor of said bipolar needle Figure 2, limited to the area of the bevel which allows focusing the area of the injured tissue to be treated without affecting healthy tissue. Also the fact that healthy tissue does not interfere with the measurement of electrical bioimpedance, allows to obtain lower values of said electrical bioimpedance of the damaged tissue, since the electrical bioimpedance of healthy tissue is not added avoiding applying high voltages to generate the electrical charge to treat injured tissue.
    Therefore, means are available to perform the self-diagnosis (2) of the degree of tissue degeneration and subsequently to calculate the electrical charge necessary for the treatment (3) by electrolysis, where said means are based, by at least one control logic (1) in the analysis of the electrical bioimpedance that the tissue presents when applying a sinusoidal signal of variable frequency by means of at least one alternating voltage generator (9) comprising an oscillator that generates a clock signal towards a direct digital synthesizer (DDS) and a D / A converter to convert said digital signal into analog; a programmable amplifier stage (10) responsible for amplifying the signal resulting from the digital / analog conversion and an impedance adapter (11) to minimize the output error of the programmable amplifier stage; an I / V converter (14) responsible for converting the current flowing through the tissue to be diagnosed to voltage. By applying said sinusoidal signal from the alternating voltage generator (9) through a bipolar needle (25) a more precise actuation of the injured area of the tissue is achieved, without affecting the healthy tissues surrounding the damage, since said needle Bipolar (25) comprises in the same bevel (6) of two electrodes (7 and 8) limiting the tissue to be explored in the proximal area of said bevel (6).
    By applying said sinusoidal signal through the bipolar needle (25) to the tissue for diagnosis, an electric current is induced that passes through the tissue between the two electrodes (7 and 8) located in the bevel (6) of the bipolar needle (25), where the intensity will depend on the electrical bioimpedance presented by the scanned tissue.
    The electrical bioimpedance may vary depending on the frequency of excitation, the different types of tissue and their condition. Said induced current circulating between
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    The two electrodes (7 and 8) of the bipolar needle (25) are measured allowing the calculation of the complex electrical bioimpedance of the explored tissue and its dissipation factor by Ohm's law.
    Generator: Current: Impedance: Dissipation Factor:
    V = V0 * sen (2n ft)
    I = 10 * sen (2nf t + y)
    image2
    image3
    The voltage obtained by means of the I / V converter (14) is amplified by a programmable amplifier stage (15) with impedance adapter and an A / D converter (16) with low pass filter for signal processing; from said processed signal an algorithm (17) is applied that allows to calculate the complex impedance and the dissipation factor of the diagnosed tissue where the results are stored in at least one memory for later comparison (18) with values obtained from a sample of healthy tissue of the patient, control sample, or with values obtained from several clinical tests to calculate the degree of degeneration of the measured tissue and the necessary electrical charge determined by the treatment module (3) by electrolysis to stimulate the regeneration of the tissues damaged through the same bipolar needle (25) being able to apply it only to the injured area of the patient's tissue without affecting the healthy tissues surrounding the damage as described.
    It is planned to have means for calibrating the device to avoid errors when performing the bioimpedance reading by means of a multiplexer (5) controlled from the control logic (1) that allows the selection to carry out the diagnosis through of the bipolar needle (25) or of performing said calibration through at least one calibration impedance (13) of known value that allows to know the impedance error that exists in the device, which will be compensated during the bioimpedance measurement of the tissue scanned
    Means for electrolysis treatment are available, selected by means of a multiplexer (5) from the control logic (1), in which the calculated electric charge is applied to generate the focused electrolysis in the affected tissue without affecting the tissue surrounding sound and avoid the need to apply high voltages, where said means comprise at least one direct current source (19) that applies the calculated electric charge to the injured tissue through the electrodes (7 and 8), anode and cathode, that are in the area of the bevel (6) of a bipolar needle (25), where it has means for controlling said electric charge based on at least one ammeter (20) that together with the control logic (1) is responsible to limit the electric charge delivered and to detect a current leak by controlling the current flowing through each electrode (7 and 8), anode and cathode, located in the bevel (6) of said bipolar needle
    (25), so that both currents are compared to determine if they exceed a safety threshold level set by the control logic (1) and the treatment (3) is stopped, and at least one voltmeter (21) that together the control logic (1) detects the difference
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    of potential between the two electrodes (7 and 8) by calculating the impedance present between both electrodes during the treatment, so that if the calculated impedance exceeds a maximum or minimum set from the control logic (1) the treatment is stopped (3) , eliminating existing contraindications in patients with endoprotesis and osteosynthesis, patients with pacemakers or any electronic implant, patients with cardiac problems, pregnant women, patients with malignant tumors and / or patients with thrombophlebitis due to the focus of the treatment and the control of possible currents of leaks
    By using the bipolar needle (25) and the security means described above, the tissues affected by the electric charge are limited to the proximal area of the bevel (6) of the bipolar needle (25), totally limiting said electric charge through the injured tissue, without affecting the surrounding healthy tissue avoiding the need to apply high tensions and eliminating existing contraindications in current devices.
    It has means to generate the focused electro-stimulation (4) aimed at stimulating the sensitive nerve fibers of the affected tissue in which bipolar pulsating signals are applied from the control logic (1) through at least two bipolar needles (26) , working these unipolar way using the central conductor of each needle as an electrode and the outer conductor as screening.
    Said pulsating signals are generated by at least one direct current generator (22) that generates a current signal pattern formed by pulses of equal amplitude and duration, but 180 ° out of phase so that the average value of said signal is null and prevents electrolysis phenomena can occur. It also has means based on at least one ammeter (23) and a voltmeter (24) that together with the control logic (1) takes control of said pulsating signal based on the measurement of the current flowing through each electrode and in the detection of a current leak measuring the current flowing through each electrode located in the central conductor of each needle so that both currents are compared to determine if it exceeds a safety threshold level set by the control logic (1) and stop the electro-stimulation (4), and also in detecting the potential difference between the two electrodes and thus calculate the impedance between both electrodes during the stimulation, so that if the calculated impedance exceeds a maximum or minimum set from the logic control (1) the electro-stimulation (4) is stopped, and thus eliminate the contraindications existing in the patients described above.
    The use of at least two bipolar needles and / or at least two isolated monopolar needles, such as teflon coating, for diagnosis, treatment and electrostimulation is also planned.
    权利要求:
    Claims (2)
    [1]
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    1. Device for diagnosis and tissue-induced regeneration by therapeutic percutaneous electrolysis and focused electro-stimulation with a bipolar needle characterized by having means for self-diagnosis focused on the area of the injured tissue to be treated without affecting the surrounding healthy tissue. where said means are based on;
    - at least one bipolar needle comprising in its bevel two electrodes located in the outer and inner conductor of this
    - a control logic that allows to apply a sinusoidal signal by means of at least one alternating voltage generator
    - an oscillator that generates a clock signal for a direct digital synthesizer (DDS)
    - a D / A converter
    - a programmable amplifier stage responsible for amplifying the signal resulting from the digital / analog conversion
    - an impedance adapter to minimize the output error of the programmable amplifier stage
    - an I / V converter in charge of converting the current flowing through the tissue to tension, said voltage is amplified by a programmable amplifier stage with impedance adapter
    - an A / D converter with low pass filter for signal processing
    - conventional means such as a memory for data storage
    - means for generating the focused electro-stimulation, where said means comprise at least one pulsing direct current generator
    - at least two bipolar needles, where the central conductor of each needle acts as an electrode and its outer conductor as a shield
    - means for the detection of current leaks circulating through each electrode asl as the difference in potential between them and the impedance by means of at least one ammeter and one voltmeter asl as a control logic that limits the maximum and minimum values.
    [2]
    2. Device for diagnosis and tissue induced regeneration by therapeutic percutaneous electrolysis and bipolar needle focused electro-stimulation according to claim 1 characterized by having means based on the use of at least one bipolar needle and at least two needles monopolars that have conventional means for their isolation, such as the teflonado coating.
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    引用文献:
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